In the manga the Deathbusters are not searching for heart crystals. Instead they want strong souls.

In the manga, Hotaru is a part cyborg

In the anime Chibi-Usa's heart crystal is stolen to awaken Mistress 9. In the manga the Mystical Silver Crystal is stolen from her.

In the manga the tailsmans do not form the Holy Grail. Instead they are the key to awakening Saturn.

In the manga the Holy Grail is formed by all of the senshi combining their powers.

In the anime Viluy comes after Tellu. In the manga Viluy comes before Tellu.

In the manga Saturn does her "Death Reborn Revolution" and then Pluto seals her away with "Dark Dome Close"

Haruka and Michiru accept Usagi as their princess and possible messiah from the beginning.

Haruka kisses Usagi in the manga.